Glenn,
I’m curious what dosage of the black seed oil and how long you used (and the typical Thymoquinone % in black seed oil) it and what was the recovery timeline in more detail. It sounded like you may have used it for 8 months, but could you give us more details on the response timeline and the effects along the way?
I notice you talk about how capsules did not seem to work for people and mentioned some higher doses in teapsoons. A capsule would have much less than a teaspoon. However, some capsule products are not black seed oil inside, but instead are extracts. For example from Triquetra and Nootropics Depot. These are extracts standardized for the Thymoquinone content with specific milligrams listed.
I would prefer to use these standardized extracts in general since I try to avoid seed oils due to their high Linoleic acid content and Black Seed Oil is very high in these. Though, I can see how that may not be a primary concern.
The Thymoquinone in the black seed oil is an Acetylcholine esterase inhibitor, meaning it will slow the breakdown of Acetylcholine. So, it will function similar to a nicotine patch. Also, if you look at Alpha-7 Nicotinic Receptor agonist you will see Nicotine is one of them, but Ivermectin is a positive allosteric modulator. So, that means Ivermectin potentiates the activity of Acetylcholine agonists, including natural Acetylcholine. That may be why it helps. Alpha-7 nicotinic receptor
I think you used the black seed oil and Ivermectin, but did not use the patch. I think I will avoid the Ivermectin. One issue I’m having with the nicotine patch and black seed oil I think is that they are making me very cold. I’m not sure if others have experienced that. I tend to get very cold too however when my digestion is not happy with certain things. I developed digestive issues at some point along the way. I think the hypothermic response is also triggered by Choline in the digestive system and read some paper on that in rats.The effects of Choline on body temperature in conscious rats
I also take a good amount of glycine and have heard that can have a cooling effect, but it wasn’t that strong for me I don’t think. Choline is just quad methyl glycine, and acetylcholine uses choline.