Tilorone: a broad spectrum antiviral from Ukraine/Russia, never approved in the West

General
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Here’s another Ukrainian drug: thiotriazoline

A Ukrainian paper claims that t’s effective in the complex treatment of patients with post-Covid syndrome

Here’s the Google machine translation of that paper:

Results. The inclusion of Thiotriazolin in the complex basic therapy of post-COVID syndrome led to a significant increase in the effectiveness of basic endothelioprotective, anticoagulant and antiaggregatory therapy and contributed to the prevention of thrombus formation. The administration of Thiotriazolin led to a significant improvement in general clinical parameters in patients with post-COVID syndrome – complaints of tachycardia disappeared, blood pressure was stabilized (without additional correction with antihypertensive drugs), weakness and increased fatigue disappeared. Saturation in 14 (93.4 %) patients increased to 97–98 %. In the control group only 7 (46.7 %) of 15 patients had oxygen saturation at 97–98 % level.
Conclusions. The introduction of the drug Thiotriazolin in the form of 200 mg tablets twice a day for 30 days into the complex basic therapy of post-COVID syndrome leads to a significant increase in the basic endothelioprotective, antiaggregatory and anticoagulant therapy and contributes to the prevention of thrombus formation against the background of improving the state of the myocardium and vascular endothelium.

The researchers’ standard treatment for post-COVID syndrome is antibiotics, anticoagulants, and acetylsalicylic acid (Aspirin).

Some hot takes on this paper

  1. The patients may not necessarily be Long COVID patients. (Long COVID as in a long list of symptoms, usually very debilitating, and the top symptoms being fatigue and PEM.) They’re people who have lingering symptoms after COVID… which is more common than the chronic Long COVID that you see in support groups.
  2. The results seem a little too good to be true (for both the standard treatment and standard plus thiotriazoline). The response rate looks extremely high judging by Table 1. Apparently Long COVID (or Post COVID which is what the paper is actually about) is very easy to treat.